一、基本信息
姓名:李东尧
学历/学位:研究生/工学博士
职务职称:副教授
所在部门:河北农业大学食品科技学院生物工程系
通讯地址:保定市乐凯南大街2596号河北农业大学食品科技学院
邮政编码:071001
联系电话:0312-7528423
电子邮箱:lidongyao@hebau.edu.cn
二、学习工作经历
2006.09~2010.06 河北北方学院 食品科学与工程 学士
2011.09~2020.08 江南大学 食品科学与工程 硕博
攻读博士学位期间,主要负责陈卫院士团队生物信息服务器poweredge r910及r920的运维,曾经手几十例肠道/发酵食品体系的菌群多样性分析工作;并协助管理气相与液相色谱、四极杆质谱与orbitrap高分辨质谱等大型仪器。接受过多家培训机构有关多组学联合分析的面授培训,以及illumina与termo fisher scientific等公司有关高通量测序与代谢组学的实验操作与分析软件培训,熟悉perl、python、r语言编程,以及shell脚本等大型运算流程pipeline的搭建。论文影响因子累计77.547,总被引频次达779次;参与2项国家自然科学基金资助课题,主要承担组学及生物信息分析工作。
2020.11至今 河北农业大学 生物工程系 副教授
三、主讲课程及研究方向
1、主讲课程:现代食品生物技术、细胞工程、发酵工程与设备
2、研究方向:食品自然发酵过程中群落结构、功能及代谢网络的演替;发酵食品功能性组分对肠道微生物及人体疾病健康的影响;多组学联合分析、深度挖掘发酵食品新资源
四、代表性论文
1. copper inhibits post-acidification of yogurt and affects its flavor: a study based on the cop operon. journal of dairy science. 2023, 106(2): 897 - 911. (co-first author, if = 4.225)
2. effect of fructo-oligosaccharides on the colonization of lactobacillus rhamnosus as 1.2466t in the gut of mice. food science and human wellness. 2023, 12(2): 607 - 613. (if = 8.022)
3. niacin inhibits post-acidification of yogurt based on the mining of ldb_rs00370 biomarker gene. food research international. 2022, 162(a): 111929. doi: 10.1016/j.foodres.2022.111929. (co-first author, if = 7.425)
4. mechanism of gastrointestinal adaptability and antioxidant function of infant‑derived lactobacillus plantarum bf_15 through genomics. food science and biotechnology. 2022, 31(11): 1451 - 1462. (co-first author, if = 3.231)
5. global transcriptomic analysis of lactobacillus delbrueckii subsp. bulgaricus atcc11842 reveals the role of ldb_rs05285 in the post-acidification of yogurt. food & function. 2021, 12(19): 9077 - 9086. (co-first author, if = 6.317)
6. potential functions of the gastrointestinal microbiome inhabiting the length of the rat digest tract. international journal of molecular sciences. 2019, 20(5), 1232. doi: 10.3390/ijms20051232. (first author, if = 6.208)
7. microbial biogeography and core microbiota of the rat digestive tract. scientific reports. 2017, 7, 45840. doi: 10.1038/srep45840. (first author, top 100 in microbiology, google scholar 130 citations)
8. lactulose differently modulates the composition of luminal and mucosal microbiota in c57bl/6j mice. journal of agricultural and food chemistry. 2016, 64(31), 6240 - 6247. (co-first author, google scholar 97 citations)
9. metagenomic insights into the effects of fructo-oligosaccharides (fos) on the composition of fecal microbiota in mice. journal of agricultural and food chemistry. 2015, 63(3): 856 - 863. (co-first author, google scholar 94 citations)
10. in vitro fermentation of lactulose by human gut bacteria. journal of agricultural and food chemistry. 2014, 62(45): 10970 - 10977. (co-first author, google scholar 50 citations)